The state of the nasopharyngeal microbiome in healthy people and in patients with chronic nasopharyngitis

Topicality: The chronic nasopharyngitis (CNP) morbidity rate tends to increase in childhood and adenoid removal is one of the most common all surgeries children. state nasopharyngeal microbiome plays significant role development inflammatory processes nasopharynx hypertrophy it considered that great progress can be made through its correction conservative treatment prevention recurrence after surgery. Traditional cultural studies which reflect only a small proportion bacteria present cannot describe real microbiome. Therefore, study quantitative qualitative composit ion essent ial for justified treatment. Aim: examine patients with CNP associated EpsteinBarr virus compare characteristics severity disease. Material methods: 20 healthy persons 32 diagnosed have been included study. composition microflora studied by determining t itres colony-forming units (CFU). findings compared features clinical course Results: individuals control group Lactobacillus spp. Bifidobacterium spp., aerobic S. salivarius, belong commensal microorganisms, as basis There has seen preservation population level flora: lactobacilli, bifidobacteria, salivary streptococci appearance opportunistic flora (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Escherichia coli) titres mild CNP. During moderate/severe course, there observed sharp decline an titer commensals. In severe cases, high titers flora, complete absence emergence pathogenic (Pneumococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa yeast-like fungi Candida type) seen. All presence disorders, regardless changes, are accompanied pharyngeal tonsil. Conclusions: Dysfunction microbiome, i.e. changes microorganisms CNP, important Minor determined reduced disease course. If reduction levels commensals observed. pathogens including albicans characterized